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Regarding ELNs, after all these years I still wish Findingsapp by @cparnot.bsky.social got resurrected. Benchling is fine, but Findings was such a joy to work with. Maybe in the age of LLMs it would be feasible to do that, add an optional web interface and collaboration features
A fascinating finding on the therapeutic potential of targeting non-coding regions of MYC!
Xuebing Wu@xuebingwu.bsky.socialDoes the noncoding genome actually carry more genetic information than coding seqs? Motivated by this question we mutated every bp in the 10kb MYC locus. Results are even more exciting: Decoding the MYC locus reveals a druggable ultraconserved RNA element www.biorxiv.org/content/10.6...
What a great thread on budgeting for an academic lab!!
Adrian Liston@labliston.bsky.social🧵How to write and manage your first research budgets The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.
Very happy that the first paper that started in our lab came out in @narjournal.bsky.social today ⭐🎊: BEscreen is a computational tool to design base editor sgRNA libraries for a broad range of use cases. It also allows for conveniently designing positive and negative controls and much more.
another great cancer biology starter pack!
Johanna Joyce@johannajoyce.bsky.socialHere's some new additions to this #Cancer #Research 🧪🔬⚕️🩺 starter pack! @marinelab.bsky.social @leilaakkari.bsky.social @carolynbertozzi.bsky.social @lydiafinley.bsky.social @ibcradiation.bsky.social and many more.. I also included some starting #PIs - welcome to you all & do give them a follow!