# Benjamin Ostendorf (@ostendorflab.org)

Profile: https://sifa.id/p/ostendorflab.org
Location: Berlin, Berlin, Germany

## Career

- **Max Eder group leader at Charité University Medicine** (Jan 2022 - Present)
  On-site
- **Attending physician (Funktionsoberarzt) at Charité University Medicine Berlin (Dpt. of Hematology/Oncology/Tumor Immunology)** (Aug 2025 - Present)
  On-site
- **Resident and Internal Medicine specialist at Charité University Medicine Berlin (Dpt. of Hematology/Oncology/Tumor Immunology)** (Jan 2022 - Jul 2025)
  Berlin, Berlin, DE
- **Postdoc at The Rockefeller University (Tavazoie Lab)** (Jun 2015 - Oct 2021)
  New York, New York, US · On-site
- **Resident at Charité University Medicine Berlin (Dpt. of Hematology/Oncology/Tumor Immunology)** (Nov 2011 - Apr 2015)
  Berlin, Berlin, DE

## Publications

- A MERTK-Targeting Antibody–Drug Conjugate Selectively Depletes M2 Tumor-Associated Macrophages and MERTK-Expressing Cancer Cells — Cancer Research (Apr 2026) http://dx.doi.org/10.1158/0008-5472.can-25-2998
- Liver-X-receptor agonism enhances T cell priming and activation to promote anti-tumor immunity — Journal of Experimental Medicine (Apr 2026) https://doi.org/10.1084/jem.20252290
- PROTECTOR / FIRE‑10: study protocol for a prospective, randomized, open-label, multicenter phase III trial to investigate the efficacy of preoperative systemic therapy in advanced colon cancer. — BMC cancer (Mar 2026) https://europepmc.org/articles/PMC13064278
- BEscreen: a versatile toolkit to design base editing libraries — Nucleic Acids Research (Jul 2025) https://doi.org/10.1093/nar/gkaf406
- Common hereditary variants of the APOE gene and posttransplant outcome in acute myeloid leukemia. — Blood (2025) https://doi.org/10.1182/blood.2024026886
- Neuronal substance P drives metastasis through an extracellular RNA–TLR7 axis — Nature (Sep 2024) https://doi.org/10.1038/s41586-024-07767-5
- Recapitulating the tumor microenvironment in a dish, one cell type at a time. — Cell Reports Methods (2024) http://www.cell.com/article/S2667237524001565/pdf
- Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression and Metastasis — Cancer Research (Sep 2023) https://doi.org/10.1158/0008-5472.CAN-23-1252
- Data from Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression and Metastasis (Sep 2023) https://doi.org/10.1158/0008-5472.c.6836999
- Common human genetic variants of APOE impact murine COVID-19 mortality — Nature (Nov 2022) https://doi.org/10.1038/s41586-022-05344-2
- Apolipoprotein E2 Promotes Melanoma Growth, Metastasis, and Protein Synthesis via the LRP1 Receptor (Oct 2022) https://doi.org/10.1101/2022.10.03.510632
- Functional genetic screen identifies ITPR3/calcium/RELB axis as a driver of colorectal cancer metastatic liver colonization. — Developmental Cell (2022) https://doi.org/10.1016/j.devcel.2022.04.010
- Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells. — Cell metabolism (Nov 2020) http://europepmc.org/abstract/med/33152324
- Tumoural activation of TLR3–SLIT2 axis in endothelium drives metastasis — Nature (Oct 2020) https://doi.org/10.1038/s41586-020-2774-y
- Common germline variants of the human APOE gene modulate melanoma progression and survival — Nature Medicine (Jul 2020) https://doi.org/10.1038/s41591-020-0879-3
- Autophagy Suppresses Breast Cancer Metastasis. — Developmental cell (Mar 2020) http://europepmc.org/abstract/med/32155434
- Apoe genotyping in cancer prognostics and treatment — World Intellectual Property Organization (WIPO) (2020)
- Germline genetic determination of cancer progression and survival (Mar 2019) https://doi.org/10.1101/576181
- Phenotypic characterization of aberrant stem and progenitor cell populations in myelodysplastic syndromes — PLOS ONE (May 2018) https://doi.org/10.1371/journal.pone.0197823
- LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer. — Cell (Jan 2018) http://europepmc.org/abstract/med/29336888
- [Flow-cytometric immunophenotyping in clinical diagnostics]. — Deutsche medizinische Wochenschrift (1946) (Oct 2016) http://europepmc.org/abstract/med/27750345
- Myeloid-derived suppressor cells in human peripheral blood: Optimized quantification in healthy donors and patients with metastatic renal cell carcinoma. (Oct 2015) http://europepmc.org/abstract/med/26462434
- Severe radiotoxicity in an allogeneic transplant recipient with a heterozygous ATM mutation. (Jul 2015) http://europepmc.org/abstract/med/24935205
- Association between low uric acid levels and acute graft-versus-host disease. (Jan 2015) http://europepmc.org/abstract/med/25172456
- BCR-ABL Mutation-Guided Therapy for CML Blast Crisis: A Case Report. (2015) http://europepmc.org/abstract/med/26379418
- Nilotinib. (2014) http://europepmc.org/abstract/med/24756785
- Synchronous tuberculosis, Epstein-Barr virus-associated lymphoproliferative disorder and cytomegalovirus infection in an allogeneic transplant recipient: a case report. (2014) http://europepmc.org/abstract/med/25019038
- A novel domain regulating degradation of the glomerular slit diaphragm protein podocin in cell culture systems. (undefined 2013) http://europepmc.org/abstract/med/23437316
- Human staphylococcus intermedius infection in a patient with postradiation changes — Infectious Diseases in Clinical Practice (2011) http://www.scopus.com/inward/record.url?eid=2-s2.0-80855163551&partnerID=MN8TOARS

## Education

- **The Rockefeller University** — PhD, Systems Cancer Biology (Jun 2020)
- **University of Freiburg** — Dr. med., Molecular Nephrology (Jan 2014)
- **University of Freiburg** — MD, Medical School (Oct 2004 - Jun 2011)
  Clinical electives at University of South Florida (Tampa, USA), Queen Mary University (London, UK), and Mount Sinai School of Medicine (New York City, USA.

## Awards

- Advanced Clinician Scientist Scholarship — German Society of Internal Medicine (Jun 2025)
- Digital Clinician Scientist — Berlin Institute of Health (Jan 2022)

## Links

- ORCID: https://orcid.org/0000-0003-4492-9252 (verified)