# Floris Groot (@floris.eu)

Profile: https://sifa.id/p/floris.eu
Headline: Anesthesioloog & Bioloog

## About

​

## Experience

- **Anesthesioloog at UMC Utrecht** (2020 – present)
- **Arts in opleiding tot anesthesioloog at UMC Utrecht** (2014 – 2019)
- **Arts in opleiding tot anesthesioloog at Rijnstate** (2015 – 2017)
- **Foundation doctor at NHS at Northwest London Hospital NHS Trust** (2013 – 2014)
  Various junior doctor jobs (FY1 and FY2) in London, UK (Cardiology, Internal Medicine, Intensive Care, Urology; at Northwick Park Hospital, Central Middlesex Hospital and Royal Marsden Hospital.)
- **Postdoctoral research fellow at University of Oxford, The Sir William Dunn School Of Pathology** (2006 – 2009)
  HIV immunology and cell biology.

## Education

- **University of Oxford** — BMBCh (2009 – 2013)
- **University of Amsterdam** — Doctor of Philosophy (Ph.D.) (2002 – 2006)
- **University of Utrecht** — Master of Science (MSc) (1996 – 2001)

## Publications

- Simulation at the Frontier of the Zone of Proximal Development: A Test in Acute Care for Inexperienced Learners. — Academic Medicine (https://pubmed.ncbi.nlm.nih.gov/32134783/)
- Macrophage Infection via Selective Capture of HIV-1-Infected CD4+ T Cells (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271767/)
- Architecture and regulation of the HIV-1 assembly and holding compartment in macrophages. (http://www.ncbi.nlm.nih.gov/pubmed/21613397)
- Efficient HIV-1 transmission from macrophages to T cells across transient virological synapses. (http://www.ncbi.nlm.nih.gov/pubmed/18296630)
- The carbohydrate at asparagine 386 on HIV-1 gp120 is not essential for protein folding and function but is involved in immune evasion. (http://www.ncbi.nlm.nih.gov/pubmed/18237398)
- Histatin 5-derived peptide with improved fungicidal properties enhances HIV-1 replication by promoting viral entry. (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16940535&query_hl=2&itool=pubmed_docsum)
- Dendritic cell-mediated HIV-1 transmission. — (ISBN: 90-8559-192-9) (http://dare.uva.nl/record/1/259411)
- Opposing roles of blood myeloid and plasmacytoid dendritic cells in HIV-1 infection of T cells: transmission facilitation versus replication inhibition. (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16705088&query_hl=20&itool=pubmed_docsum)
- Differential susceptibility of naïve, central memory and effector memory T cells to dendritic cell-mediated HIV-1 transmission. (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&list_uids=16916447&dopt=Abstract%22)
- Dendritic cell-mediated HIV-1 transmission to T cells of LAD-1 patients is impaired due to the defect in LFA-1. (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17078873&query_hl=3&itool=pubmed_docsum%22)
- Stimulated plasmacytoid dendritic cells impair human T cell development. (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16917011&query_hl=4&itool=pubmed_docsum)
- Lactoferrin prevents dendritic cell-mediated HIV-1 transmission by blocking the DC- SIGN—gp120 interaction. (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15709021&query_hl=3&itool=pubmed_docsum)
- Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4+ T-lymphocytes. (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16239964&query_hl=3&itool=pubmed_docsum)
- Initiation of HIV-1 reverse transcription is regulated by a primer activation signal. (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11384976&query_hl=3&itool=pubmed_docsum)
- Stabilization of the U5-leader stem in the HIV-1 RNA genome affects initiation and elongation of reverse transcription. (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11058109&query_hl=3&itool=pubmed_docsum)
- Sialoadhesin (CD169) expression in CD14+ cells is upregulated early after HIV-1 infection and increases during disease progression. (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17330143&query_hl=3&itool=pubmed_docsum)

## Other profiles

- linkedin: https://www.linkedin.com/in/florisgroot